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Toxicological information

Toxic effects on livestock and pets

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Administrative data

Endpoint:
toxic effects on livestock and pets
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Already evaluated by the Competent Authorities for Biocides and Existing Substance Regulations.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Trace elements in soils and pasture herbage on ferms with bovine hypocupraemia
Author:
Leech, A.F. and Thornton, I.
Year:
1987
Bibliographic source:
J agric. Sci., Camb. (1987), 108, 591-597

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Purity: No data

Results and discussion

Applicant's summary and conclusion

Executive summary:

The importance of molybdenum, sulphur, iron, zinc and cadmium dietary antagonists to ruminant copper metabolism was investigated at the farm level in an attempt to explain the widespread occurence of bovine hypocupraemia in recent years.

From 22 of the most severely hypocupraemic regions of England, six areas with as wide a range of geological, pedological and topological situations as possible were selected for detailed field work. This involved the collection of topsoil and herbage samples from approximately 15 farms per area with hypocupraemic stock. Possible causal factors of bovine hypocupraemia were then considered on the basis of three citeria: critical concentrations of copper, molybdenum, sulphur, iron, zinc and cadmium in pasture herbage; Cu:Mo rations in herbage; and copper availability predictions for ruminants.

Absolute copper deficiency and molybdenum-induced bovine hypocupraemia were clearly demonstrated at the farm level. The results also confirmed that dietary sulphur, in particular, plays a significant yet previously unrecognized role in the widespread incidence of bovine hypocupraemia in industrialized Britain. Antagonism due to iron orgination from soil-contaminated herbage was evident, but not common. No evidence was found to support the occurrence of zinc- or cadmium-induced hypocupraemia in the areas examined.