Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats exposed to test substance in air for up to 8 hr and subsequently observed for 14 d.
GLP compliance:
no
Remarks:
study predates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Decanal
EC Number:
203-957-4
EC Name:
Decanal
Cas Number:
112-31-2
Molecular formula:
C10H20O
IUPAC Name:
decanal
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-Decanal (mixed isomers)
- Substance type: Aldehyde
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE
- For exposure duration ≥ 0.25 hr, Vapour/air mixture was generated by passing 2.5 L of dried air at room temperature through a fritted glass disc immersed to a depth of 1 inch (2.54 cm) in approx. 50 mL of test chemical contained in a gas-washing bottle.
- For exposure duration ≤ 10 mins, static technique used, whereby 50 g to 100 g of substance were spread over a shallow tray 200 square inches (1290 cm²) is placed in a 120 L sealed chamber for ≥ 24 hr. Rats were then rapidly introduced by means of a drawer-type cage designed to minimise vapour loss.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
>= 0.033 - <= 8 h
Remarks on duration:
2 min, 5 min, 10 min, 15 min, 30 min, 1 hr, 2 hr, 4 hr, 8 hr
Concentrations:
1 concentration; doses dependent on exposure time
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No data

Results and discussion

Effect levels
Sex:
male/female
Remarks on result:
other: No mortality was observed up to the highest exposure of 8 hr duration
Mortality:
0/6
Clinical signs:
other: No data
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Conclusions:
The test substance was assessed for acute inhalation toxicity using exposure of rats to the test substance for up to 8 hours. No mortality was observed in the longest exposure period of 8 hours.