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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats exposed to test substance in air for up to 8 hr and subsequently observed for 14 d.
GLP compliance:
no
Remarks:
study predates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Decanal
EC Number:
203-957-4
EC Name:
Decanal
Cas Number:
112-31-2
Molecular formula:
C10H20O
IUPAC Name:
decanal
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-Decanal (mixed isomers)
- Substance type: Aldehyde
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE
- For exposure duration ≥ 0.25 hr, Vapour/air mixture was generated by passing 2.5 L of dried air at room temperature through a fritted glass disc immersed to a depth of 1 inch (2.54 cm) in approx. 50 mL of test chemical contained in a gas-washing bottle.
- For exposure duration ≤ 10 mins, static technique used, whereby 50 g to 100 g of substance were spread over a shallow tray 200 square inches (1290 cm²) is placed in a 120 L sealed chamber for ≥ 24 hr. Rats were then rapidly introduced by means of a drawer-type cage designed to minimise vapour loss.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
>= 0.033 - <= 8 h
Remarks on duration:
2 min, 5 min, 10 min, 15 min, 30 min, 1 hr, 2 hr, 4 hr, 8 hr
Concentrations:
1 concentration; doses dependent on exposure time
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No data

Results and discussion

Effect levels
Sex:
male/female
Remarks on result:
other: No mortality was observed up to the highest exposure of 8 hr duration
Mortality:
0/6
Clinical signs:
other: No data
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Conclusions:
The test substance was assessed for acute inhalation toxicity using exposure of rats to the test substance for up to 8 hours. No mortality was observed in the longest exposure period of 8 hours.