Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-831-9 | CAS number: 7758-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed poublication
Data source
Reference
- Reference Type:
- publication
- Title:
- Repeated dose oral toxicity study of the test chemical
- Author:
- Webster et al
- Year:
- 1 959
- Bibliographic source:
- Toxicology and Applied Pharmacology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- The subacute (28 days) study was conducted to evaluate the toxic effects of repeated administration of the test chemical to guinea pigs by the oral route.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- Molecular formula:
- HIO3.K
- IUPAC Name:
- potassium iodate
- Details on test material:
- - Name of test material: Potassium iodate
- Molecular formula: IO3K
- Molecular weight: 213.995 g/mol
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: Beltsville
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: N/A
- Housing:Each animal was housed in a separate cage
- Diet (e.g. ad libitum):dry Purina Rabbit Chow ad libitum
- Water (e.g. ad libitum):ad libitum
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on oral exposure:
- 1st group : 12.5 mg/kg bw/day KIO3 in the drinking water.
2nd group : 125 mg/kg bw/day KIO3
3rd group (Control group):Control group was given distilled water. - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0,12.5, 62.5,125 mg/kg bw/day
Basis:
- No. of animals per sex per dose:
- Control: 6 males and 6 females
12.5 mg/kg bw/day: 6 males and 6 females
125 mg/kg bw/day:6 males and 6 females - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Because the 125 mg/kg bw/day KI03 group drank so little, the iodate concentration was reduced to 62.5 mg/kg bw/day after the fourteenth day.
Examinations
- Observations and examinations performed and frequency:
- BODY WEIGHT: Yes
- Average body weight examined.
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Yes
Total water consumption observed.
OPHTHALMOSCOPIC EXAMINATION: Yes
The eyes of each one were examined microscopically.
HAEMATOLOGY: Yes
Blood samples were taken from two males and females in each group 5-6 days before the end of the 4-week experimental period.
Following parameters were examined:
red cell count, hematocrit, hemoglobin, white cell count, and differential counts - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
Sacrifice : yes
The animals were killed with ether and given a postmortem examination.
HISTOPATHOLOGY: Yes
Microscopically organs were studied in only a few animals in each group. - Statistics:
- No data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- smaller gain in body weight
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- consumed less iodate
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- effects observed, treatment-related
- Description (incidence and severity):
- Water consumption increased
- Ophthalmological findings:
- no effects observed
- Description (incidence and severity):
- No retinal degeneration was observed.
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- Blood examinations failed to show any striking changes
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- No adverse effects observed
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- No gross changes were observed on postmortem examination.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Details on results:
- All animals remained in good physical condition during the 4-week study period.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 125 other: mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Basis for effects : Haematology, Histopathology, Opthalmoscopic examination, Gross pathology
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a sub acute repeated dose toxicity study of the test chemical, it showed no effect on male and female guinea pigs when present in the diet at a level upto 125 mg/kg bw/day (0.50 % concentration) for a 28 days study period. Thus the NOAEL (no observed adverse effect level) for repeated dose oral toxicity was considered to be 125 mg/kg bw/day.
- Executive summary:
The study was designed to investigate the subacute repeated dose toxicity effects of the test chemical to Beltsville guinea pigs(male/female) by oral route in an overall estimation period of 28 days. First group (6 animals per sex in each dose group) was fed a dry Purina Rabbit Chow in the drinking water equivalent to 12.5 mg/kg bw/day (0.05 % concentration) test chemical in the diet. The second group received only the test chemical equivalent to125 mg/kg bw/day (0.50 % concentration), and the third group as control received distilled water. During the study period body weight, haematology, histopathology, opthalmoscopic examination, gross pathology, water consumption, total body weight and compound intake were examined. The blood examinations failed to show any striking changes related to the target compound. All animals remained in good physical condition during the 4-week study period. No gross changes were observed on postmortem examination and no retinal degeneration or other significant histologic changes were noted. Thus from overall dissussion of the study, the NOAEL (no observed adverse effect level) for repeated dose oral toxicity was considered to be 125 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.