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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation, other
Remarks:
In Vivo study
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Early non-GLP/non-guideline study, adequate for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: list VIII
Author:
Carpenter, CP, Weil, CS and Smyth, HF
Year:
1974
Bibliographic source:
Toxicol Appl Pharmacol 28, 313-319

Materials and methods

Principles of method if other than guideline:
The degree of injury was assessed following instillation of phenyl ethyl alcohol into the eye.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Phenylethyl alcohol
IUPAC Name:
Phenylethyl alcohol

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Details on study design:
Eye irritation was recorded using a 10 -point scale, based upon the degree of corneal necrosis that
resulted from instillation of various volumes/concentrations of the test substance into the rabbit eye i.e.
Grade 1 = very small area of necrosis after instillation of 0.5 ml undiluted substance;
Grade 5 = severe chemical burn after instillation of 0.005 ml undiluted substance;
Grade 10 = severe chemical burn after instillation of 0.5 ml of 1% dilution of substance;

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Score:
8
Max. score:
10
Reversibility:
not specified
Remarks on result:
other: Results from this non-standard test indicate severe corneal corrosion

Applicant's summary and conclusion

Interpretation of results:
other: Irritant to eye
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Irritant to eye
Executive summary:

An acute eye irritation study was conducted by Carpenter et al. (1973) during a range- finding toxicity study. The test was carried on using New Zealand White rabbits. Eye irritation was recorded using a 10 -point scale, based upon the degree of corneal necrosis that resulted from instillation of various volumes/concentrations of the test substance into the rabbit eye. The score recordered was 8 of 10. Based on the condition of the study, phenylethyl alcohol was considered to be an eye irritant.