Registration Dossier
Registration Dossier
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EC number: 619-484-5 | CAS number: 895525-72-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU7OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- {[2-(trifluoromethyl)phenyl]formamido}methyl acetate
- EC Number:
- 619-484-5
- Cas Number:
- 895525-72-1
- Molecular formula:
- C11H10F3NO3
- IUPAC Name:
- {[2-(trifluoromethyl)phenyl]formamido}methyl acetate
- Test material form:
- solid: crystalline
Constituent 1
Test system
- Vehicle:
- physiological saline
- Amount / concentration applied:
- 25 mg per insert plus 50 µL 0.9% NaCl to moisten and ensure good contact with the skin
- Duration of treatment / exposure:
- 60 min
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: viability
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 61.96
- Irritation parameter:
- other: viability
- Basis:
- mean
- Time point:
- other: 3 min
- Score:
- 102.29
- Irritant / corrosive response data:
- Tested on the skin/epidermal equivalents in triplicate.
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The results show that no corrosive property of the test item was determined by the assay used.
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