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EC number: 201-758-7 | CAS number: 87-62-7
The study was performed according to OECD 405. Three rabbits were exposed to 0.1 mL test substance; eyes were not washed out. The animals were observed for 8 d.
Slight corneal opacity, iritis and chemosis were completely reversible within 8 d. Moderate conjunctivae redness was not fully reversible in 2/3 animals within 8 d. However, a clear trend over time for decreasing effect strength was observable, and in 1/3 animals the redness was completely reversible. As additional effect, contracted pupils as reversible effect in all animals (a sign for iritis) and scars on the eyelid in 2/3 animals at the end of the observation period were observed. Since a observation period of 21 d was not exhausted as recommended in the actual guideline, the complete reversibility of the relevant conjunctivae redness can only be assumed.
Based on the effect of the temporarily constricted eyelids as sign for iritis, 2,6 -xylidine has to be considered as eye irritant Cat. 2A according to GHS requirements). The criteria are not met for R36 according to EU classification.
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