Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Reference
Reference Type:
publication
Title:
Studies of the syncopic effect of aniline derivatives on Fish. The problem concerning the determination of median lethal concentration in fish.
Author:
Tonogai Y, Ogawa S, Ito Y and Iwaida M
Year:
1983
Bibliographic source:
Eisei Kagaku 29(5): 280-285. (Only abstract, tables and figures in English)

Materials and methods

Principles of method if other than guideline:
Method: other: Acute toxicity test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
TS-Freetext:
2,6-Dimethylaniline

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Cyprinus sp.
Details on test organisms:
TEST ORGANISM
- Common name: carp
-

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
48 h

Test conditions

Details on test conditions:
- number of fish/vessel: 10
- test vessel: 10-l aquaria
- flow-through system
- temperature: 25 °C
- duration: 48 h
- observations: death, behaviour (syncopic state: lying sideways)
- measurements: test substance via GC-FTD

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
other: SC50
Effect conc.:
66 mg/L
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
112 mg/L
Basis for effect:
mortality

Any other information on results incl. tables

Excretion of test substance was also measured via GC-FTD.
The test substance was excreted by all test species within 4 h.

Applicant's summary and conclusion