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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
11/10/2021
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Estimated data generated using the EPI suite program developed by the USEPA

Data source

Reference
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: R6 guidance on QSARS and READ across
Principles of method if other than guideline:
Prediction done using BCFBAF (v3.01) model
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Butylamine
EC Number:
203-699-2
EC Name:
Butylamine
Cas Number:
109-73-9
Molecular formula:
C4H11N
IUPAC Name:
butan-1-amine
Radiolabelling:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
other: Fish

Study design

Route of exposure:
aqueous
Water / sediment media type:
natural water: freshwater

Test conditions

Test temperature:
25°C

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
ca. 44.22 L/kg
Depuration
Key result
Rate constants
Key result
Value:
3.162
Remarks on result:
other: Non-bioaccumulative

Any other information on results incl. tables

SMILES : NCCCC


CHEM : Butylamine


MOL FOR: C4 H11 N1


MOL WT : 73.14


 


BCFBAF v3.01


Summary Results:


Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)


Biotransformation Half-Life (days) : 0.215 (normalized to 10 g fish)


Log BAF (Arnot-Gobas upper trophic): 0.25 (BAF = 1.78 L/kg wet-wt)


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BCF (Bioconcentration Factor):


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Log Kow (estimated) : 0.83


Log Kow (experimental): 0.97


Log Kow used by BCF estimates:0.97


 


Correction(s): Value


No Applicable Correction Factors


 


Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)

Applicant's summary and conclusion

Conclusions:
The bio concentration factor (BCF) of butylamine was estimated to be 3.162 L/kg at 25°C. Which does not exceed the concentration threshold of 2000 indicating that the chemical is not expected to bio accumulate in the food chain.
Executive summary:

BCFBAF model (V3.01) of Estimation Programs interface (EPI Suite, 2017) was used to predictt the bioconcentration factor (BCF) of test chemical  Butylamine cas109-73-9. The  bio concentration factor (BCF) of Butylamine  was estimated to be 3.162 L/kg wet -wt (at 25 °C).Which does not exceed the concentration threshold of 2000 indicating that the chemical is not expected to bio accumulate in the food chain.