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Diss Factsheets
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EC number: 204-614-1 | CAS number: 123-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report with restrictions (limited information on test item, animal husbandry and results).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Dilauryl Thiodipropionate
- Author:
- Liebert MA
- Year:
- 1 992
- Bibliographic source:
- Journal of the american college of toxicology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Deviations:
- yes
- Remarks:
- (limited information on test item and animal husbandry, no data on maternal toxicity/food and water consumption)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Didodecyl 3,3'-thiodipropionate
- EC Number:
- 204-614-1
- EC Name:
- Didodecyl 3,3'-thiodipropionate
- Cas Number:
- 123-28-4
- Molecular formula:
- C30H58O4S
- IUPAC Name:
- didodecyl 3,3'-sulfanediyldipropanoate
- Details on test material:
- - Name of test material (as cited in study report): Dilauryl thiodipropionic acid
- Physical state: fine white powdered material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data, virgin
- Weight at study initiation: average 217 g
- Fasting period before study: no data
- Housing: individually housed in mesh bottom cages
- Diet: ad libitum
- Water (fresh): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): controlled, but no further details given
- Humidity (%): controlled, but no further details given
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- VEHICLE
- Amount of vehicle (if gavage): 1mL/kg bw - Analytical verification of doses or concentrations:
- no
- Details on mating procedure:
- Females were mated with young adult males, and observation of the vaginal sperm plug was considered Day 0 of gestation.
- Duration of treatment / exposure:
- Day 6 and continuing daily through Day 15 of gestation
- Frequency of treatment:
- daily
- Duration of test:
- During pregnancy until caesarian on day 20.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
16, 74, 350 and 1600 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 20 or 21, depending on the group
- Control animals:
- yes, sham-exposed
- Details on study design:
- 250 mg/kg of aspirin was used as a postive control.
Attention was called to the fact that this is the seventeenth of a series of reports performed for the US FDA. Eventually, a total of at least 42 compounds were planned to be tested in 21 pairs; each pair being run concurrently against one sham-treated control and one positive control group. Because
of the inherent variability of biological data of the type dealt with. Here, the accumulation and pooling of sequential sets of control values would greatly enhance the statistical value of the findings and the ultimate reliability of the test results.
Examinations
- Maternal examinations:
- Body weights were recorded on Days 0, 6, 11, 15, and 20 of gestation. All animals were observed daily for appearance and behaviour with particular attention to food consumption and weight, in order to rule out any abnormalities which may have occurred as a result of anorexic effects in the pregnant female animal.
- Ovaries and uterine content:
- On Day 20 all dams were subjected to caesarean section under surgical anesthesia, and the numbers of implantation site and resorption sites were recorded. The urogenital tract of each dam was examined in detail for anatomical normality. The number of live and dead fetuses were recorded.
- Fetal examinations:
- The body weights of the live pups were recorded.
All foetuses were examined grossly for the presence of extemal congenital abnormalities. One-third of the foetuses of each litter underwent detailed visceral examinations employing 10x magnification. The remaining two-thirds were cleared in potassiiam hydroxide (KOH), stained with alizarin red dye and examined for skeletal defects. - Statistics:
- not performed
- Historical control data:
- Not available at the time of reporting.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Details on maternal toxic effects:
The method part states that clinical signs were assessed, but no further details were given in the results part.
No mortalitiy occured and the body weight development was not affected.
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 600 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Basis for effect level:
- other: other:
Maternal abnormalities
- Abnormalities:
- not specified
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 600 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Remarks:
- Highest dose tested. No clearly discernible effect on nidation or on maternal or foetal survival. The number of abnormalities seen in either soft or skeletal tissues of the, test groups did not differ from the number occurring spontaneously in the sham-treated controls.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Treatment with aspirin at 250 mg/kg bw resulted in an increased number of resorptions, dead foetuses, missing, bipartitie or incompletely ossified sternebrae, incompletely ossified vertebrae and incompletely closed skulls.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.