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EC number: 271-091-4 | CAS number: 68515-49-1
The fate of DIDP was evaluated in 6 male Sprague Dawley rats (mean body weight 200 g) receiving head only exposure to 14C-DIDP aerosol atmosphere nominal concentration: 100 mg/m3 for 6 hours (General Motors Research Laboratories, 1981). The mass median aerodynamic diameter of DIDP aerosol was 0.98 μm. Three animals were sacrificed immediately following exposure, the remaining animals at the end of the 72-hour collection period. Feces were collected at 24-hour intervals and urine was collected at 12-hour intervals for 72 hours. The radioactivity was determined by liquid scintillation spectrometry.
Absorption: Total body burden following the exposure was 6.75 μmole equivalents or approximately 3 mg. Radioactivity derived from 14C -DIDP was excreted in urine and feces during the 72-hour post-exposure collection period: 45.3% and 41%, respectively, of the total body burden. At the end of the collection period following exposure, 9.4% of the absorbed dose of radioactivity was recovered from carcass and tissues, 2.4% from skin and 1.6% from cage wash.
Distribution: The distribution of radioactivity in rat tissues immediately following exposure, indicated the highest concentration of radioactivity was in lung followed by GIT, liver and kidney. The remaining tissues contained far lesser amounts. Radioactivity was below detection limit in brain, spleen and testes.
Elimination: After 72 hours the concentration was decreased in all tissues. The highest level of radioactivity was still found in lung which contained 27% of the content of radioactivity present immediately following exposure. The pulmonary load decreased to a lesser extent than all the tissues except fat which did not appear to change. Radioactivity derived from 14C -DIDP was excreted in urine and feces during the 72-hour post-exposure collection period: 45.3% and 41%, respectively, of the total body burden. The excretion of radioactivity in urine during the 72-hour collection period following inhalation exposure was best described using first order kinetics. Based on 12-hour interval excretion data, the half-life (T½) of elimination was 16 hours with an elimination rate constant Ke of 0.042/hour. Radioactivity derived from 14C -DIDP was excreted in urine (45.3%) and feces (41.3%) during the 72-hour post-exposure collection period. An additional 1.6% was recovered in washings of the metabolic cage collection surfaces and was derived from urine and fecal contamination. From these data 88% of the total absorbed dose of the radioactivity was excreted from the body, and the carcass retention data imply that a small fraction of DIDP or metabolites was retained in the body for a longer period of time. Using total recovered radioactivity to represent body content or body burden of 14C immediately following exposure, and given urinary and fecal interval excretion data, an estimate of the disappearance of radioactivity from the whole body with time can be obtained. The decline in body burden was linear with an apparent first order with T½ of 26 hours and an elimination rate constant Ke of 0.027/h.
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