Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Inhaled DIDP aerosol seems readily absorbed. It can be assumed that a fraction of insoluble particles are cleared from the nasopharyngeal region and swallowed. In the same way, in the tracheobronchial tree the mucociliary transport system leads deposited particles upward to the oropharynx where they are swallowed and pass through the GI tract. Thus, a 75% bioavailability estimate seems reasonable. DIDP content in fat tissue is very low, but remains constant from the end of exposure to the end of the observation period (72 hours). Excretion is shared between urine and feces.

Dermal absorption of DIDP is very low by comparison to the inhalation route.

At low doses approximately 50% of orally administered DIDP is absorbed.  DIDP is metabolized to monoester and is excreted via kidney and liver.  Elimination of orally administered DIDP is complete within 72 hours.