Registration Dossier
Registration Dossier
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EC number: 200-652-8 | CAS number: 67-43-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation is insufficient for assessment with minimal reporting of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- On the influence of Ca-DTPA on delta-aminolevulinic acid dehydratase in rats
- Author:
- Planas-Bohne, F.
- Year:
- 1 977
- Bibliographic source:
- 379. [Experientia]
Materials and methods
- Type of study / information:
- On the influence of Ca-DTPA on delta-aminolevulinic acid dehydratase in rats
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Calcium salt of DTPA
- IUPAC Name:
- Calcium salt of DTPA
- Details on test material:
- - Name of test material: Ca-DTPA
Constituent 1
Results and discussion
Any other information on results incl. tables
The administration of Ca-DTPA leads to an inhibition of red cell ALAD only after toxic doses or with fractionated treatment. Zn-DTPA does not have any effect on the enzyme in any case.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, the administration of Ca-DTPA leads to an inhibition of red cell ALAD only after toxic doses or with fractionated treatment. Zn-DTPA does not have any effect on the enzyme in any case.
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