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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1977
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation is insufficient for assessment with minimal reporting of results.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
On the influence of Ca-DTPA on delta-aminolevulinic acid dehydratase in rats
Author:
Planas-Bohne, F.
Year:
1977
Bibliographic source:
379. [Experientia]

Materials and methods

Type of study / information:
On the influence of Ca-DTPA on delta-aminolevulinic acid dehydratase in rats
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Not applicable
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Ca-DTPA

Results and discussion

Any other information on results incl. tables

The administration of Ca-DTPA leads to an inhibition of red cell ALAD only after toxic doses or with fractionated treatment. Zn-DTPA does not have any effect on the enzyme in any case.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the study, the administration of Ca-DTPA leads to an inhibition of red cell ALAD only after toxic doses or with fractionated treatment. Zn-DTPA does not have any effect on the enzyme in any case.