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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.64 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Dose descriptor starting point:
LOAEL
Value:
100 mg/kg bw/day
Value:
123 mg/m³
Explanation for the modification of the dose descriptor starting point:

Default (DNEL calculator)

Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
2.33 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Dose descriptor starting point:
LOAEL
Value:
100 mg/kg bw/day
Value:
700 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:

Default (DNEL calculator)

Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.29 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Dose descriptor starting point:
LOAEL
Value:
100 mg/kg bw/day
Value:
43.5 mg/m³
Explanation for the modification of the dose descriptor starting point:

Default (DNEL calculator)

Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.833 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Dose descriptor starting point:
LOAEL
Value:
100 mg/kg bw/day
Value:
500 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:

Default (DNEL calculator)

Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
medium hazard (no threshold derived)

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.167 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
Oral
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Dose descriptor starting point:
LOAEL
Value:
100 mg/kg bw/day
Value:
100 mg/kg bw/day
Explanation for the modification of the dose descriptor starting point:

Default (DNEL calculator)

Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Justification:
Default (DNEL calculator)
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
medium hazard (no threshold derived)

Additional information - General Population