Registration Dossier

Administrative data

Endpoint:
immunotoxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in Japanese.

Data source

Reference
Reference Type:
publication
Title:
Effects of ethylenethiourea on the functions of mouse lymphocytes.
Author:
Teshima R, Ikebuchi H and Terao T.
Year:
1982
Bibliographic source:
Eisei Skikensho Hokoku 100: 44-48

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Other name : Ethylenethiourea (ETU)

Test animals

Species:
mouse
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Doses / concentrations
Remarks:
Doses / Concentrations:
460 mg/kg
Basis:

Results and discussion

Results of examinations

Details on results:
Ethylenethiourea suppressed the primary and secondary immune response in  mice and to a lesser extent also inhibited the primary immune response mitogen-stimulated lymphocyte proliferation in vitro. Studies in T cells revealed that ethylenethiourea suppressed the activity of both helper T cells and suppressor T cells.

Applicant's summary and conclusion