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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-guideline study with limited details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Principles of method if other than guideline:
Pre-guideline study
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Anhydrous diethylhydroxylamine #2697
- Analytical purity: no data
- Lot/batch No.: no data

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Four albino rabbits were used at each of four dosage levels. Individual doses were applied to the fur-clipped skin of the trunk under a pre-fitted occluding sleeve on each animal. The sleeves were renoved 24 hours later and surviving animals were observed for seven days.
Doses:
707, 1000, 1414, 2000 mg/kg
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 300 mg/kg bw
95% CL:
995 - 1 690
Mortality:
Skin dose(mg/kg)  No.rabbits(dead/total)   Time for deaths (hours) 

707                     0/4                -   -    -  -  
1000                    1/4                -   -    -  >26
1414                    2/4                -   -   <20, >26
2000                    4/4              <20, <20, <20, >26
Clinical signs:
Hypersensitivity, mydriasis, and incoordination prior to toxic incapacitation.
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Executive summary:

In a pre-guideline study, groups of 4 albino rabbits were treated dermally under a pre-fitted occluding sleeve with 707, 1000, 1414 and 2000 mg/kg body weight of diethylhydroxylamine. The occluding sleeve was removed 24 hours following exposure and the animals were observed for 7 days. No rabbit died at 707 mg/kg/bw, at 1000 mg/kg bw, 1/4 rabbit died, at 1414 mg/kg bw, 2/4 rabbits died and at 2000 mg/kg bw, all rabbits died. The clinical signs observed were hypersensitivity, mydriasis, and incoordination prior to toxic incapacitation. The acute dermal LD50was 1300 mg/kg bw.