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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-guideline study with limited details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
Pre-guideline study
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-diethylhydroxylamine
EC Number:
223-055-4
EC Name:
N,N-diethylhydroxylamine
Cas Number:
3710-84-7
Molecular formula:
C4H11NO
IUPAC Name:
N-ethyl-N-hydroxyethanamine
Details on test material:
- Name of test material (as cited in study report): Diethylhydroxylamine #2697
- Analytical purity: no data
- Lot/batch No.: no data

Test animals

Species:
rat
Strain:
other: WBS/W
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1400, 2000, 2800, 4000 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 190 mg/kg bw
Based on:
test mat.
Mortality:
Oral dose(mg/kg) No.rats(dead/total) mortality time for death (hours)
1400 0/5 -
2000 2/5 -, -, -, >5, >24
2800 4/5 -, >3, >5,>24,>24
4000 5/5 >2, 5, 5, >5, >5
Clinical signs:
Muscular incoordination and general depression. Autopsy findings were negative.
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a pre-guideline study, groups of 5 WBS/W rats were administered dose levels of 1400, 2000, 2800, 4000 mg/kg bw of diethylhydroxylamine (undiluted) by stomach tube. The animals were then observed for 7 days following exposure. At 4000 mg/kg, 5/5 rats died, at 2800 mg/kg bw 4/5 rats died, at 2000 mg/kg bw, 2/5 rats died and at 1400 mg/kg bw none died. Clinical observations revealed muscular incoordination and general depression. Autopsy findings were negative.The LD50was 2190 mg/kg bw.