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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
other: acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-Iminodiethanol, propoxylated
EC Number:
500-085-9
EC Name:
2,2'-Iminodiethanol, propoxylated
Cas Number:
35176-06-8
Molecular formula:
C4H11O2N(C3H6O)n; n = 1 – 6.5
IUPAC Name:
2,2'-Iminodiethanol, propoxylated
Details on test material:
- Physical state: viscous liquid
- Content: > 99%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Statistics:
none: limit test

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
none
Clinical signs:
none
Body weight:
Two female rats showed a slight decrease in bodyweight 1 week after exposure.
Gross pathology:
no noticable gross pathological findings

Applicant's summary and conclusion

Executive summary:

5 male and 5 female rats were dosed dermally with 2000 mg/kg bw. There were no mortalities, nor any other clincal signs observed. The slight decrease in body weight gain of the two females in the first week is assumed to be caused by the stress of the application procedure.

The acute dermal toxicity is low with an LD50 value exceeding 2000 mg/kg bw in rats of both sexes.