Registration Dossier
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EC number: 252-161-3 | CAS number: 34708-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
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- Additional physico-chemical properties of nanomaterials
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The key study for skin irritation found very slight irritant effects to the skin of rabbit, below the EU threshold for classification (Asta-Werke AG, 1987). The study was conducted according to OECD 404 and in compliance with GLP.
The key eye irritation study was conducted according to OECD 405 and in compliance with GLP and found the test material to be a non-irritant when applied undiluted to the eyes of rabbits (Asta-Werke AG, 1987).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 January 1987 to 19 January 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive application (semi-occlusive recommended), temperature of 22 ± 2 °C (20 ± 3 °C recommended)
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EEC
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: White Russian (Albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ASTA-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 5 to 8 months
- Weight at study initiation: 2.20 to 2.45 kg
- Housing: singly in stainless tell cages type ASTA
- Diet: standard diet ad libitum
- Water: ad libitum
- Acclimation period: at least one day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 13 January 1987 To: 30 January 1987 - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: one test patch and one untreated control patch was applied to the dorsal area of each animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- ~6 days (observation times: 1, 24, 48 and 72 hours after patch removal, and 6 days after application)
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: 6.25 cm2
- % coverage: no data
- Type of wrap if used: linen cloth secured by synthetic film glue, with an occlusive bandage wrapped around the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data
SCORING SYSTEM: Draize method (see "Any other information on materials and methods incl. tables") - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Two animals displayed erythema immediately after patch removal. One animal developed erythema 24 hours after patch removal. In all cases, erythema was grade one, except at 24 hours in one of the animals displaying an immediate reaction, when grade 2 erythema was observed. In each case, erythema was still visible at 72 hours, however, not at five days after patch removal.
Grade 1 oedema was seen in one animal 24 hours after patch removal. This was no longer visible 48 hours after patch removal. - Other effects:
- There was no evidence of systemic toxicity or mortality throughout the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study carried out according to OECD Test Guideline 404, (triethoxy(3-cyanatopropyl)silane) was slightly irritating (by Draize criteria) to the skin of rabbits when applied under occlusion for 4 hours, with an overall irritation index of 1.1.
- Executive summary:
In a study carried out according to OECD Test Guideline 404, (triethoxy(3-cyanatopropyl)silane) was tested for its skin irritation potential in rabbits.
0.5 ml of undiluted test substance was applied under occlusion to the shaved skin of three male rabbits for 4 hours. Patches not containing the test substance were also applied to the skin of the same three males to act as concurrent control regions. Rabbits were then observed at 1, 24, 48 and 72 hours after patch removal, and 6 days after application. Skin reactions were graded according to the Draize system.
Very slight erythema was observed in all test animals, starting within 24 hours of patch removal (in two animals, an immediate reaction was observed). In one rabbit, erythema became well-defined at 24 hours, and was accompanied by very slight oedema. Oedema was not seen in any other animal, or at any other time point. All signs of irritation were fully reversible within 6 days of application. There were no signs of systemic toxicity or mortality throughout the study.
Triethoxy(3-cyanatopropyl)silane was judged to be slightly irritating according to Draize criteria (i.e. an irritation index between 0.6 and 3.0), based on an irritation index of approximately 1.1, calculated from the sum of mean scores for erythema (1.0) and oedema (0.8). On the basis of this test the test substance would not be classified as irritating according to EU criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 January 1987 to 29 January 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- temperature of 22 ± 2 °C (20 ± 3 °C recommended).
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EEC
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: White Russian (Albino)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: ASTA-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 6 to 7 months
- Weight at study initiation: 2.40 to 2.85 g
- Housing: singly in stainless steel cages type ASTA
- Diet: standard diet ad libitum
- Water: ad libitum
- Acclimation period: at least one day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 20 January 1987 To: 23 January 1987 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: one eye of each animal left untreated
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- 3 days
- Observation period (in vivo):
- 3 days (at 1, 24, 48 and 72 hours after application)
- Number of animals or in vitro replicates:
- 1 male, 2 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM: Draize system (see "Any other information on materials and methods incl. tables")
TOOL USED TO ASSESS SCORE: Cliptrix pencil light - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- sum of evaluation scores for three eye sections - mean over all timepoints
- Score:
- 2
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: See "Any other information on materials and methods incl. tables" for information on derivation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- discharge
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No observable effects on the cornea or iris were observed.
Hyperaemia or redness (grade 1 or 2) was seen in the conjunctiva at 1 and 24 h after application. This was resolved within two days of application.
Slight swelling (grade 1) or swelling with partial eversion of lids (grade 2) each occurred in one animal within one hour of treatment and resolved within 24 hours.
Slight discharge was noted in one animal within one hour of application only. - Other effects:
- There were no overt signs of systemic toxicity or mortality over the duration of the study.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a study carried out to OECD Test Guideline 405, (triethoxy(3-thiocyanatopropyl)silane) was non-irritating when applied undiluted to the eyes of rabbits.
- Executive summary:
In a study carried out in accordance with OECD Test Guideline 405, (triethoxy(3-thiocyanatopropyl)silane) was tested for its potential to cause eye irritation in rabbits.
0.1 ml of the undiluted test material was applied to one eye of each of three rabbits (two males and one female), with the other eye left as an untreated control. Observations were made 1, 24, 48 and 72 hours after application.
There were no overt signs of systemic toxicity or mortality throughout the course of the study. Application of the test substance had no apparent effect on the cornea or iris. Conjunctival redness and hyperaemia was observed in all treated animals within 24 hours, and was fully resolved within 48 hours. Slight swelling and discharge were seen in the treated eye of one animal, and swelling with partial eversion of lids was seen in another. These effects were only evident during the first 24 hours following application.
An overall irritation index of 2 was calculated and the test material was considered to be non-irritation to eyes (according to Draize criteria) under the conditions of the test. It would not be classified as an eye irritant by EU criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key skin irritation study was conducted according to OECD 404 and in compliance with GLP (Asta-Werke AG, 1987). The test material was noted to be slightly irritating to rabbit skin following occlusive application. Very slight erythema was observed in all test animals, starting within 24 hours of patch removal (in two animals, an immediate reaction was observed). In one rabbit, erythema became well-defined at 24 hours, and was accompanied by very slight oedema. Oedema was not seen in any other animal, or at any other time point. All signs of irritation were fully reversible within 6 days of application. There were no signs of systemic toxicity, or mortality throughout the study.
The key study for eye irritation was conducted according to OECD 405 and in compliance with GLP (Asta-Werke AG, 1987). No apparent effect on the cornea or iris were observed. Conjunctival redness and hyperaemia were observed in all treated animals within 24 hours. However, effects were fully resolved within 48 hours. Slight swelling and discharge were seen in the treated eye of one animal, and swelling with partial eversion of lids was seen in another. These effects were only evident during the first 24 hours following application. There were no overt signs of systemic toxicity or mortality throughout the course of the study.
There is no indication of corrosivity in any of the available studies.
Justification for classification or non-classification
Based on the available information, no classification is required for skin or eye irritation in accordance with Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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