Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-787-6 | CAS number: 2235-00-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 5.75 mg/L
Additional information
According to Annex XI, Section 1.3 of REACH, results obtained from valid qualitative or quantitative structure-activity
relationship models ((Q)SARs) may indicate the presence or absence of a certain dangerous property. Results of (Q)SARs may be used instead of testing when the following conditions are met:
— results are derived from a (Q)SAR model whose scientific validity has been established,
— the substance falls within the applicability domain of the (Q)SAR model,
— results are adequate for the purpose of classification and labelling and/or risk assessment, and
— adequate and reliable documentation of the applied method is provided.
The long-term toxicity on aquatic invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d NOEC for reproduction of Daphnia magna was derived using a trend analysis of the standardized workflow for ecotoxicological endpoints as provided by the Toolbox (BASF SE, 2020). The resulting 21‑d NOEC was 5.75 mg/L. The Substance is within the applicability domain of the model. The robust study summary for this endpoint contains all relevant and required information. Therefore, the Registrant will not perform a study on the long-term toxicity to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
