Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-831-3 | CAS number: 88-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism and Biliary Exeretion of Arylaminosulphonic Acids in the Rat
- Author:
- McMahon K.A. & O´reilly W.J.
- Year:
- 1 969
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol. 7, pp. 497-500
Materials and methods
- Objective of study:
- excretion
- metabolism
- Principles of method if other than guideline:
- In vivo study in rats to gather information about the metabolism and the bilary excretion of Arylaminosupphonic acids including 4-aminotoluene-3-suphonic acid.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- Molecular formula:
- C7H9NO3S
- IUPAC Name:
- 2-amino-5-methylbenzene-1-sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): 4-aminotoluene-3-suphonic acid
The compounds were obtained commercially or provided by the respective Department, and were purified by recrystallization.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The animals (250-350 g body weight) were starved overnight.
Administration / exposure
- Route of administration:
- other: oral: gavage or intravenous
- Vehicle:
- other: alkaline aqueous solution
- Details on exposure:
- - Amount of solution: 10 mg
- Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg, presumably per animal (ca. 30-40 mg/kg bw)
- No. of animals per sex per dose / concentration:
- 3 (urinary excretion)/ 5 (biliary excretion)
- Control animals:
- no
- Details on dosing and sampling:
- Urine was collected over a 24-hr period following oral or intravenous administration and was assayed first for free acid and then, after acid hydrolysis, for metabolite, by a method based on the procedure of Bratton & Marshall (1939), 0.1 N-HCl being substituted for trichloracetic acid. Biliary excretion of the compounds was studied by injecting the acid into the femoral arterial vein of rats anaesthetized with urethane (1.25 g/kg) and collecting bile samples over a 6-hr period via a biliary cannula. The cannulation of the bile duct and the preparation of bile samples for assay have been described previously (Priestly & O'Reilly, 1966).
Results and discussion
Main ADME resultsopen allclose all
- Type:
- excretion
- Results:
- Oral administration: Percentage of dose recovered as free acid in the urine after 24 h: 21.0 +-2.2%
- Type:
- excretion
- Results:
- Oral administration: Percentage of dose recovered as conjugate in the urine after 24 h: 0%
- Type:
- excretion
- Results:
- Intravenous administration: Percentage of dose recovered as free acid in the urine after 24 h: 59.0 +-6.8%
- Type:
- excretion
- Results:
- Intravenous administration: Percentage of dose recovered as conjugate in the urine after 24 h: 0%
- Type:
- excretion
- Results:
- Intravenous administration: Percentage of dose recovered as free acid in the bile after 6 h: 0.79%
- Type:
- excretion
- Results:
- Intravenous administration: Percentage of dose recovered as conjugate in the bile after 6 h: 0%
Any other information on results incl. tables
Of the fifteen compounds examined, only six showed evidence of metabolism involving conjugation of the a amino group (4-aminotoluene-3-suphonic acid did not). It. must be stressed that in no case was all of the compound accounted for so there may have been other metabolites from which the amino group had been removed and which were therefore undetectable by the Bratton-Marshall assay. In general, oral administration gave rise to lower total recoveries of the compounds but a greater degree of metabolism than intravenous dosage.
As conjugation of these compounds was not extensive, only slight biliary exeretion of the acids was expected based on their molecular weights range in the rat (below 300). The measured results indicate an increase in biliary excretion of the larger acids and their metabolites, but in no case was this excretion extensive.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.