Strontium nitrate

Endpoint summary

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Additional information

Allen et al used strontium chloride hexahydrate as test material for skin irritation testing:

Read across from SrCl2 to Sr(NO3)2 is envisaged due to the fact that possible effects occurred could be regarded as strontium ion related effects. Both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water. Hence, it could be concluded that read across is possible.

Justification for selection of skin irritation / corrosion endpoint:
reliable GLP guideline study available

Justification for selection of eye irritation endpoint:
reliable GLP guideline study available

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin irritation:

Reference Verbaan (2010) is considered as the key studies for in vitro skin irritation and will be used for classification. The overall irritation result is as follows:

Relative viability: mean after 15 min incubation 118%; evaluated by MTT reduction.

 

The classification criteria according to regulation (EC) 1272/2008 as irritating to skin are not met since the mean rel. viability is >50% of the control, hence no classification required. The in vitro study according to the draft EC method B.46 (EpiSkin^TM) was validated and considered of being a reliable and relevant stand-alone test for predicting rabbit skin irritation, and for being used as a replacement of in vivo method OECD 404 for the purposes of distinguishing between R38 skin irritating and non-skin irritating test substances (ECVAM, 27.04.2007).

Eye irritation:

Reference Stitzinger (2010) is considered as the key study for eye irritation and will be used for classification. The overall irritation results are as follows:

Cornea score: 0 (in all animals at 24, 48 and 72h);

Iris score: 0 (in all animals at 24, 48 and 72h); Conjunctivae score: 2 (in all animals at 24, 48 and 72h); Chemosis score: max. 2 (in all animals).

The conjunctiva irritation observed in two animals was not fully reversible within 21 days. Therefore the substance has to be classified as eye damage substance and should be labelled with H318: Causes serious eye damage

Respiratory irritation:

The classification as respiratory irritant is covered under the endpoint specific target organ toxicity- single exposure and repeated exposure. Please refer to the endpoint summaries on acute toxicity (endpoint 7.2) and repeated dose toxicity (endpoint 7.5) for further information.