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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
1981
Report date:
1981
Reference Type:
review article or handbook
Title:
Report to RIFM, 01 July 1977
Author:
Epstein Wl Report to RIFM, 01 July 1977 (cited from Opdyke 1979)
Year:
1977
Bibliographic source:
Research Institute for Fragrance Materials, cited in Opdyke (1981)
Report date:
1977
Reference Type:
publication
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Maximization test according to Kligman and Epstein (1975)
GLP compliance:
no
Type of study:
other: maximization test

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyric acid
EC Number:
203-532-3
EC Name:
Butyric acid
Cas Number:
107-92-6
Molecular formula:
C4H8O2
IUPAC Name:
butyric acid
Details on test material:
- Name of test material (as cited in study report): n-butyric acid, n-butanoic acid (RIFM no. 77-60)
- no further information reported

In vivo test system

Test animals

Species:
human

Results and discussion

Any other information on results incl. tables

No sensitization reaction was produced by the test substance (1% in petrolatum) in the test system used.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information