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EC number: 203-532-3 | CAS number: 107-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11.10.1983 - 25.10.1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyric acid
- EC Number:
- 203-532-3
- EC Name:
- Butyric acid
- Cas Number:
- 107-92-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- butyric acid
- Details on test material:
- - Name of test material (as cited in study report): n-Buttersäure
- Physical state: colorless liquid
- Analytical purity: 99,8 %
- Lot/batch No.: RM 132465
- Storage condition of test material: under darkness, 2 ° C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Age at study initiation: no data
- Weight at study initiation: 3.3 - 3.7 kg
- Housing: in individually cages in air-conditioned rooms
- Diet: Altromin 2123, Altromin GmbH, ad libitum
- Water: deionized chlorinated water, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 ml on a 2.5 x 2.5 cm patch - Duration of treatment / exposure:
- 1 hour
- Observation period:
- 0.5-1, 24, 48, 72 hrs after removal of the patch and at day 7 and 14
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: special wound healing patches, Fa. Beiersdorf AG, Hamburg, covered and fixed with a semiocclusive bandage
REMOVAL OF TEST SUBSTANCE
- removal of test substance without washing as far as possible
- Time after start of exposure: 1 -2 hours
SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: all animals
- Reversibility:
- not reversible
- Remarks on result:
- other: scoring not possible due to severe skin hardening and discoloration in all animals at all time points
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours after patch removal
- Score:
- 1.9
- Max. score:
- 3
- Reversibility:
- not reversible
Any other information on results incl. tables
After removal of the patch, the treated skin of the test animals was discolored greenish, after one day in became brownish. One animal showed severe redness round the exposed area. In the course of observation period the treated skin surface hardened. It became dry, brittle and bulged. After 14 days, severe effects could still be observed. Two animals showed ablation of skin and beginning scarring. One animal had a reddish lesion where the test material had been applicated.
Scoring for erythema and edema (maximum score = 4
|
Erythema |
Edema |
||||||||||
|
1 h |
24 h |
48 h |
72 h |
7 d |
14 d |
1 h |
24 h |
48 h |
72 h |
7 d |
14 d |
Rabbit 1 |
* |
* |
* |
* |
* |
* |
3 |
3 |
2 |
1 |
* |
* |
Rabbit 2 |
* |
* |
* |
* |
* |
* |
2 |
2 |
3 |
2 |
* |
* |
Rabbit 3 |
* |
* |
* |
* |
* |
* |
2 |
2 |
1 |
1 |
* |
* |
* scoring not possible due to severe skin hardening and discoloration
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information R 34 Criteria used for interpretation of results: EU
- Conclusions:
- Butyric acid caused corrosion of the rabbit's skin after a 1-hour contact period
- Executive summary:
In a valid GLP OECD 404 study 3 rabbits were exposed dermally to a single dose of 0.5 ml of undiluted TS for a period of one hour. Butyric acid was corrosive as evidenced by skin lesions, severe hardening and discolouring which persisted until the end of the 14 -day observation period (Hoechst AG, 1983).
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