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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
year of publication: 2002
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary source
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
European Union Risk Assessment Report - o-Anisidin
Author:
European Chemicals Bureau
Year:
2002
Bibliographic source:
European Commission, Joint Research Center, EUR 19834 EN, 2nd Priority list, Volume 15

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
o-anisidine
EC Number:
201-963-1
EC Name:
o-anisidine
Cas Number:
90-04-0
Molecular formula:
C7H9NO
IUPAC Name:
2-methoxyaniline

Results and discussion

Signs and symptoms of toxicity:
yes
Remarks:
ataxia, lacrimation, eyelid constriction, ruffeled fur, at day 1 post application urine was orange
Dermal irritation:
yes
Remarks:
very slight to moderate irritative effects 30 min post application which were all reversible within 72 h

Any other information on results incl. tables

Dermal resorption can be assumed from other studies on toxicity of o-anisidine.

Applicant's summary and conclusion

Conclusions:
There were no in vivo studies specifically dealing with the metabolism of o-anisidine. However, from effects observed in toxicological studies it can be assumed that o-anisidine is resorbed after dermal application.

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