Strontium chloride

Endpoint summary

Description of key information

Strontium chloride is not skin irritant but damaging to the eyes which is a strontium ion related effect.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Additional information

Read across from Sr(NO3)2 to SrCl2 is envisaged and fully justified since possible effects occurred during testing could be regarded as strontium ion related effects. Furthermore, both substances (SrCl2 and Sr(NO3)2) are "very soluble" (above 10 g/L at 20°C) in water.

Justification for selection of skin irritation / corrosion endpoint:
The study performed by Allen (1997) is used as key study since the study is an in vivo study performed with strontium chloride which fulfills the requirements of regulation (EC) 1907/2006. Whereas, the study performed by Verbaan (2010) is an in vitro study and strontium nitrate was used as test substance. This study is only used as supportive information.

Justification for selection of eye irritation endpoint:
Only one study available.

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin irritation:
Reference Allen (1997) is considered as the key studies for in vivo skin irritation and will be used for classification. The overall irritation result is as follows:

Erythema & edema score:0 (in all animals at 24, 48 and 72h)

The classification criteria according to regulation (EC) 1272/2008 as irritating to skin are not met since no effects were observed, hence no classification required.

 

Eye irritation:

Reference Stitzinger (2010) is considered as the key study for eye irritation and will be used for classification. The overall irritation results are as follows:

Cornea score: 0 (in all animals at 24, 48 and 72h);

Iris score: 0 (in all animals at 24, 48 and 72h); Conjunctivae score: 2 (in all animals at 24, 48 and 72h); Chemosis score: max. 2 (in all animals).

The conjunctiva irritation observed in two animals was not fully reversible within 21 days. Therefore the substance has to be classified as eye damage substance and should be labelled with H318: Causes serious eye damage

 

Respiratory irritation:

The classification as respiratory irritant is covered under the endpoint specific target organ toxicity- single exposure and repeated exposure. Please refer to the endpoint summaries on acute toxicity (endpoint 7.2) and repeated dose toxicity (endpoint 7.5) for further information.