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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted standards
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1954

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Follows basic principles of an OECD401 but there is insufficient information to rank it as 'equivalent or similar'. A number of the observations normally now required are not reported.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl maleate
EC Number:
203-328-4
EC Name:
Dibutyl maleate
Cas Number:
105-76-0
Molecular formula:
C12H20O4
IUPAC Name:
dibutyl but-2-enedioate
Details on test material:
No data.

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Source - Commercial supplier
Weight at study - 90 to 120 g
Diet - fed Rockland rat diet complete
Group - 5 rats/group
Acclimation period - 14 days

Administration / exposure

Route of administration:
other: by intubation
Vehicle:
not specified
Details on oral exposure:
Test substance was diluted with water, corn oil, or 1% solution of sodium 3,9-diethyl-6-tridecanol sulfate when necessary to maintain the volume between 1 and 10 ml. Fourteen days after dosing, mortality was completed.
No. of animals per sex per dose:
5 males per group
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 3 730 mg/kg bw
Remarks on result:
other: no data on confidence limits
Mortality:
Fourteen days after dossing mortality was considered completed.
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 >= 3730 mg/kg bw (2680 - 5210 mg/kg bw) for rats.
Executive summary:

The toxic effects of DBM were assessed in an acute oral test with Carworth-Wistar rats. Animal were exposed to the test substance via intubation. The LD50 was determined to be > than 3730 mg/kg bw.