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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-Oxydiethanol, propoxylated
EC Number:
500-031-4
EC Name:
2,2'-Oxydiethanol, propoxylated
Cas Number:
9051-51-8
Molecular formula:
C4 H10 O3 (C3 H6 O) n, where n average >1 and n<4.5
IUPAC Name:
2,2'-Oxydiethanol, propoxylated
Details on test material:
- Physical state: Liqiud
- content: > 99%
- chemical name: 2,2´-Oxydiethanol, propoxylated (>1>4,5 mol PO)

Test animals

Species:
rabbit
Strain:
other: Crl: KBL(NZW)BR
Details on test animals or test system and environmental conditions:
according to guideline
sex of the test animals: female

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: The surrounding untreated skin served as control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
4 hours
Observation period:
1, 24, 48 and 72 hours after patch removal. If dermal irritation was observed, additional monitoring on day 7 and 14 after patch removal was done.
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1-#3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal: #1-#3
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
4
Other effects:
There were no systemic intolerance reactions.

Applicant's summary and conclusion

Executive summary:

An acute dermal irritation/corrosion test (OECD 404) was performed with Diethyleneglycol, propoxylated. According to classification criteria Diethyleneglycol, propoxylated is not an irritant to the skin. There were no systemic intolerance reactions.