Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
other: acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-Oxydiethanol, propoxylated
EC Number:
500-031-4
EC Name:
2,2'-Oxydiethanol, propoxylated
Cas Number:
9051-51-8
Molecular formula:
C4 H10 O3 (C3 H6 O) n, where n average >1 and n<4.5
IUPAC Name:
2,2'-Oxydiethanol, propoxylated
Details on test material:
- Physical state: liquid
- Content: > 99%
-Chemical Name: 2,2´-Oxydiethanol, propoxylated (>1<4.5 mol PO)

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Statistics:
none: limit test

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
none
Clinical signs:
none
Body weight:
no substance related effect
Gross pathology:
no noticable gross pathological findings

Applicant's summary and conclusion

Executive summary:

The acute dermal toxicity is low with an LD50 value exceeding 2000 mg/kg bw in rats of both sexes.