Registration Dossier
Registration Dossier
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EC number: 500-031-4 | CAS number: 9051-51-8 1 - 4.5 moles propoxylated
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-Oxydiethanol, propoxylated
- EC Number:
- 500-031-4
- EC Name:
- 2,2'-Oxydiethanol, propoxylated
- Cas Number:
- 9051-51-8
- Molecular formula:
- C4 H10 O3 (C3 H6 O) n, where n average >1 and n<4.5
- IUPAC Name:
- 2,2'-Oxydiethanol, propoxylated
- Details on test material:
- - Physical state: liquid
- Content: > 99%
-Chemical Name: 2,2´-Oxydiethanol, propoxylated (>1<4.5 mol PO)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Statistics:
- none: limit test
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- no noticable gross pathological findings
Applicant's summary and conclusion
- Executive summary:
The acute dermal toxicity is low with an LD50 value exceeding 2000 mg/kg bw in rats of both sexes.
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