Registration Dossier
Registration Dossier
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EC number: 500-031-4 | CAS number: 9051-51-8 1 - 4.5 moles propoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Japan MAFF Testing Guideline of 12 Nosan No. 8147 as this in line with OECD 423
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-Oxydiethanol, propoxylated
- EC Number:
- 500-031-4
- EC Name:
- 2,2'-Oxydiethanol, propoxylated
- Cas Number:
- 9051-51-8
- Molecular formula:
- C4 H10 O3 (C3 H6 O) n, where n average >1 and n<4.5
- IUPAC Name:
- 2,2'-Oxydiethanol, propoxylated
- Details on test material:
- - Physical state: liquid
- Purity: 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- animals approx. 10 weeks; animals of comparable weight (172 -182 g).
single housing with free access to drinking water and food throughout the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- two groups of 3 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: 6/6 female rats showed impaired and poor general state, dyspnoea, gasping, staggering, abdominal position, piloerection and ataxia at hour 1 until hour 5 after administration
- Gross pathology:
- no macroscopic pathological findings
Applicant's summary and conclusion
- Executive summary:
Under the conditions of this study the median lethal dose of the test substance after oral administration was found to be greater than 2000 mg/kg bw in rats.
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