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Diss Factsheets
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EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (in vivo): not irritating (method similar to OECD404)
Eye irritation not irritating (according to OECD405)
Respiratory irritation: not irritating (based on the non irritant properties of skin and eye)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The skin irritating potential of Cyclaprop in rabbits was determined in an acute skin irritation study which was performed according to a method similar to OECD404. New Zealand White rabbits were exposed to Cyclaprop for 4 hours (semi-occlusive), after which the patch was removed and exposure sites wiped clean. The skin sites were assessed immediately after treatment and 24, 48 and 72 hours after treatment.
Cyclaprop produced a mild reaction 24 hours after treatment, which decreased at 48 and 72 hr. The mean erythema scores over the 24, 48 and 72 hour time period, were 0 (1 animal), 0.67 (4 animals) and 1 (3 animals). The mean edema scores over the 24, 48 and 72 hour time period, were 0 (1 animal), 0.67 (2 animals), 1 (4 animals), and 1.33 (1 animal). As all animals had scorings below 2.3, the test substance is not considered to be a skin irritant.
Eye irritation
The potential of Cyclaprop to cause eye irritation was determined according to OECD guideline 405. Four New Zealand White female rabbits were exposed to 0.1 ml of the undiluted test article in one of the eyes. The other eye served as a control. The eyes were examinated and the changes graded according to a numerical scale one hour, 24, 48, 72 hours after dosing. The animals showed very slight signs of irritation on the treated eyes. Mean corneal opacity, chemosis, and iris scores at the 24, 48, and 72 hour time point were 0 in all animals. Mean conjunctivae score was 0.33 in three animals and 0 in one animal. The effects seen in the one animal was reversible within one day. It is concluded that Cyclaprop is not an eye irritant.
Respiratory irritation
For respiratory irritation mostly human data are used for the assessment because no suitable in vitro or in vivo tests are available that can identify respiratory irritation (REACH guidance R.7.2.3). There are no human data available such as indicated in part R7.2.3 of the ECHA guidance that indicate respiratory reactions of the substance e.g. from consumer experience or occupational exposure. In addition, the substance is not corrosive or severely irritating (absence of classification and labelling for skin and eye irritation) which further minimizes the respiratory irritation hazard (REACH guidance: 7.2.1.2).
Justification for classification or non-classification
Based on the available corrosion and irritation information the substance does not need to be classified for skin, eye and irritation according to EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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