3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate

Long-term toxicity to fish

Description of key information

An early life-stage toxicity test was performed with the fathead minnow (Pimephales promelas) according to OECD TG 210 (v. 2013) and in compliance with GLP standards. Fish eggs aged less than 24 h were exposed in a flow-through system for 33 days (5 days to hatching and 28 days post hatch). Dimethyl formamide was used to prepare the stock solutions. A solvent control was included. Nominal test concentrations were 0.31, 0.63, 1.3, 2.5 and 5.0 mg/L whereas the mean measured concentrations were 0.20, 0.38, 0.80, 1.5 and 3.4 mg/L, respectively. These levels represented between 60 and 68% of the nominal concentrations. There were no significant differences between the effects in the control and the solvent control and so the data were pooled. The results are based on the mean measured concentrations. No significant treatment-related effects on survival were noted at concentrations up to and including 3.4 mg/L, whereas survival was affected starting at 1.5 mg/L. Sublethal effects (behaviour and morphology) were seen starting at a concentration of 1.5 mg/L and above. Growth (measured as total length, wet and dry weight), larval survival and sublethal effects were the determining endpoint with 33d-NOEC = 0.8 mg/L. The LOEC was 1.5 mg/L and the MATC was 1.1 mg/L. The lowest 33d-EC10 value was 0.91 (0.049 - 1.1) mg/L for survival; the 33d-EC20 value was 1.2 (0.97 - 1.3) mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

EC10

Effect concentration:

0.91 mg/L