Phenol, 4-methyl-, reaction products with dicyclopentadiene and isobutylene

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 August 2016 to 15 September 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Mass median aerodynamic diameter:

1.358 µm

Geometric standard deviation:

>= 1.757 - <= 1.762

Key result

Percentile:

D10

Mean:

0.353 µm

St. dev.:

0

Key result

Percentile:

D50

Mean:

0.716 µm

St. dev.:

0.001

Key result

Percentile:

D90

Mean:

1.622 µm

St. dev.:

0.007

Full test results:

	RUN 1	RUN 2	RUN 3	RUN 4	RUN 5	**Average
Volume weighted mean	1.047	1.038	1.039	1.037	1.034	1.039
Median (d50)	0.717	0.716	0.716	0.715	0.715	0.716
Mode (um)	0.687	0.688	0.687	0.687	0.687	0.687
*MMAD	1.360	1.359	1.359	1.357	1.357	1.358
10% of material is <	0.353	0.353	0.353	0.353	0.353	0.353
50% of material is <	0.717	0.716	0.716	0.715	0.715	0.716
90 % of material is <	1.635	1.621	1.623	1.617	1.614	1.622

AII results are in um

* Mass Median Aerodynamic Diameter

**Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

99.56 % by volume of sample was seen to be < 10.00μm.

Standard deviation results:

Run No.	1	2	3	4	5	STOVP	% STOVP
d10	0.353	0.353	0.353	0.353	0.353	0.000	0.0
d50	0.717	0.716	0.716	0.715	0.715	0.001	0.1
d90	1.635	1.621	1.623	1.617	1.614	0.007	0.4
d15.78	0.407	0.407	0.407	0.407	0.407	0.000	0.0
GSD	1.762	1.759	1.759	1.757	1.757	0.002	0.1
MMAD	1.36	1.36	1.36	1.36	1.36	0.00	0.1

GSD = Geometric standard deviation

STDVP = standard deviation of the population

% STDVP = percentage standard deviation of the population

Coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.

Conclusions:

In a laser diffraction test conducted in accordance with GLP, the mass median aerodynamic diameter (MMAD) was found to be 1.358 um. 90% of the material was < 1.622 um.

Description of key information

In a laser diffraction test (conducted in accordance with GLP), the mass median aerodynamic diameter (MMAD) was found to be 1.358 um and 90% of the material was < 1.622 um.