Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-300-3 | CAS number: 56-93-9
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- publication
- Title:
- Synthesis and Skeletal Muscle Relaxant Activity of Quaternary Ammonium Salts of Dantrolene and Clodanolene
- Author:
- ELLIS,. K. 0. , WHITE, Jr., R. L, WRIGHT, G. C.and . WESSELS, F. L
- Year:
- 1 980
- Bibliographic source:
- Journal of Pharmaceutical Sciences Vol. 69. No. 3 (March 1980) pp 327-331
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Direct stimulation of the gastrocnemius muscle in rats was examined.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Benzyltrimethylammonium chloride
- EC Number:
- 200-300-3
- EC Name:
- Benzyltrimethylammonium chloride
- Cas Number:
- 56-93-9
- Molecular formula:
- C10H16N.Cl
- IUPAC Name:
- benzyltrimethylazanium chloride
- Details on test material:
- Benzyltrimethylammonium chloride was purchased from Aldrich Chemical Company. No further details provided.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: TAC:SD/NfBr
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: tetrahydrofurfuryl alcohol
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- No data.
- Frequency of treatment:
- Rats received a single iv treatment
- Post exposure period:
- No additional information available.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25 mg/kg
Basis:
other: iv administered dose
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
- Details on results:
- The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Conclusions:
- The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
- Executive summary:
The effect of the test material on muscle was evaluated. The maximum percent change in Gastrocnemius Muscle Twitch Response following iv administration of 25 mg/kg benzyltrimethylammonium chloride was 10.1 +/- 1.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
