Registration Dossier
Registration Dossier
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EC number: 203-813-0 | CAS number: 110-89-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable according to OECD criteria.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of piperidine (CAS 110-89-4) (Q)SAR results were used to support results of biodegradation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment
The key study was performed according to OECD 301 C (MITI-I) with a mixed inoculum by MITI Japan (1992). The test material concentration was 100 mg/L, the inoculum concentration 30 mg/L. The biodegradation rate was determined to be 67% BOD after a period of 14 days. TOC and test material analysis indicate a degradation above 90%.
Additionally, the biodegradation of piperidine was determined using the QSAR model CATALOGIC 301C v.11.16 implemented in OASIS Catalogic v.5.14.1.5. The model predicted an O2-consumption (BOD) of 72% after 28d (Primary Half Life = 9.88 days; Ultimate Half Life = 15.18 days).
In conclusion, the test substance is readily biodegradable according to OECD criteria.
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