Registration Dossier
Registration Dossier
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EC number: 203-924-4 | CAS number: 111-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
To evaluate the sensitising potential of diethylen glycon dimethylether a read-across to the structural and toxicological similar diethylen glycol methylethylether was performed.
Diethylen glycol methylethylether did not show any sensitising potential in a LLNA.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitising potential of diethylene glycol methyl ethyl ether was tested in one Local Lymph Node Assay (LLNA) according to OECD test guideline 429. In this assay S.I. of 0.73, 1.03, and 0.69 were determined with the test item at concentrations of 25%, 50% and 100% in acetone:olive oil (4 +1).
In this assay no EC3 value could be calculated since all S.I. values were below 3.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the compound from the LLNA study. Therefore, it is concluded that the subsance is not a respiratory sensitizer.
Justification for classification or non-classification
Diethylene glycol dimethylether and siethylene glycol methylethylether, which is tested for its sensitising potential, belong to the glycol ether family. These substances have been demonstrated to be very similar in structure, physical/chemical properties and the toxicological profile. Due to the fact that diethylene glycol dimethylether and diethylene glycol methylethyl ether have nearly the same chemical structure (especially with reference to the functional groups):
1. Diethylene glycol dimethyl ether: H3C-O-CH2-CH2-O- CH2 -CH2 -O-CH3
2. Diethylene glycol methyl ethyl ether:H3C-O-CH2-CH2-O -CH2-CH2-O-CH2-CH3
the same mode of interaction with living cells and tissue is expected. Therefore, a read across from diethylene glycol dimethylether to data obtained with diethylene glycol methylethylether is scientifically justified.
Diethylene glycol methylethylether did not show skin sensitizing properties in the LLNA study according to the current OECD guidelines. Allergic skin reactions or case reports of acute contact dermatitis to diethylene glycol dimethylether have not been described in the literature. Therefore, diethylene glycol dimethylether does not have to be classified as a skin sensitizer.
A classification concerning respiratory sensitizing properties is not warranted as the classification criteria according to EU regulation 1272/2008 are not met.
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