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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 July - 14 July 1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well performed and documented study anaolgue to "Inhalation Hazard Test" OECD guideline 403. No LC50 derivable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 403, 5. Annex: Inhalation Hazard Test
Deviations:
yes
Remarks:
nose-only exposure
GLP compliance:
no
Remarks:
study performed before GLP guidelines
Test type:
other: Inhalation Hazard Test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
colorless, clear liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males 234-250g, females 200-220g

- Housing:
- Diet (e.g. ad libitum): 1324, ad libitum
- Water (e.g. ad libitum): community tap water, ad libitum

ENVIRONMENTAL CONDITIONS
- Housing: Macrolon cages with softwood bedding
- Temperature (°C): 22°C


IN-LIFE DATES: From: To: 10. july - 24. July 1979

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
nose only
Vehicle:
clean air
Details on inhalation exposure:
Each rat was placed in a plastic tube, which were connected to the inhalation chamber (20 L volume). Exposure was by nose exclusively. Diethylene glycol dimethyl ether was applied to a vaporizer and continuously evaporated. The resulting test substance/air mixture was carried to the inhalation chambers using an air stream of 600 L/h. Diethylene glycol dimethyl ether consupmtion was determined by weighing before study start and at study termination.

Temperature: 21.9 - 22.0°C
Pressure: 1010 mbar
Exposure duration: 7 h
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
11.1 mg/L (7 hours), 6 males, 6 females
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical - daily, weighing - weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopy
Statistics:
none

Results and discussion

Preliminary study:
None
Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
11 mg/L air
Exp. duration:
7 h
Remarks on result:
other: test substance saturated atmosphere
Mortality:
0/12 animals (7 h, 11 mg/L)
Clinical signs:
No effects
Body weight:
No effects
Gross pathology:
No effects
Other findings:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information LC0: 11 mg/L for 7 h Criteria used for interpretation of results: expert judgment
Conclusions:
The LC0 of Diethylene glycol dimethyl ether after 7 h inhalation exposure is 11 mg/L.
Executive summary:

One group of 6 male and 6 female Wistar rats were exposed to a saturated Diethylene glycol dimethyl ether atmosphere at a concentrations of 11.1 mg/L for 7 hours. All animals survived without irreversible clinical signs or macroscopic findings. Body weight was not effects.