Bis(2-methoxyethyl) ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 July - 14 July 1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well performed and documented study anaolgue to "Inhalation Hazard Test" OECD guideline 403. No LC50 derivable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD 403, 5. Annex: Inhalation Hazard Test

Deviations:

yes

Remarks:

nose-only exposure

GLP compliance:

no

Remarks:

study performed before GLP guidelines

Test type:

other: Inhalation Hazard Test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-methoxyethyl) ether

EC Number:

203-924-4

EC Name:

Bis(2-methoxyethyl) ether

Cas Number:

111-96-6

Molecular formula:

C6H14O3

IUPAC Name:

1-methoxy-2-(2-methoxyethoxy)ethane

Constituent 2

Reference substance name:

Diethylene glycol dimethyl ether

IUPAC Name:

Diethylene glycol dimethyl ether

Constituent 3

Reference substance name:

Diglyme

IUPAC Name:

Diglyme

Details on test material:

colorless, clear liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males 234-250g, females 200-220g

- Housing:
- Diet (e.g. ad libitum): 1324, ad libitum
- Water (e.g. ad libitum): community tap water, ad libitum

ENVIRONMENTAL CONDITIONS
- Housing: Macrolon cages with softwood bedding
- Temperature (°C): 22°C


IN-LIFE DATES: From: To: 10. july - 24. July 1979

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose only

Vehicle:

clean air

Details on inhalation exposure:

Each rat was placed in a plastic tube, which were connected to the inhalation chamber (20 L volume). Exposure was by nose exclusively. Diethylene glycol dimethyl ether was applied to a vaporizer and continuously evaporated. The resulting test substance/air mixture was carried to the inhalation chambers using an air stream of 600 L/h. Diethylene glycol dimethyl ether consupmtion was determined by weighing before study start and at study termination.

Temperature: 21.9 - 22.0°C
Pressure: 1010 mbar
Exposure duration: 7 h

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

7 h

Concentrations:

11.1 mg/L (7 hours), 6 males, 6 females

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical - daily, weighing - weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopy

Statistics:

none

Results and discussion

Preliminary study:

None

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC0

Effect level:

11 mg/L air

Exp. duration:

7 h

Remarks on result:

other: test substance saturated atmosphere

Mortality:

0/12 animals (7 h, 11 mg/L)

Clinical signs:

other: No effects

Body weight:

No effects

Gross pathology:

No effects

Other findings:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LC0 of Diethylene glycol dimethyl ether after 7 h inhalation exposure is 11 mg/L.

Executive summary:

One group of 6 male and 6 female Wistar rats were exposed to a saturated Diethylene glycol dimethyl ether atmosphere at a concentrations of 11.1 mg/L for 7 hours. All animals survived without irreversible clinical signs or macroscopic findings. Body weight was not effects.