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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information



For Diglyme short-term aquatic ecotoxicity studies for all three trophic levels (fish, daphnia and algae) are available as well as studies on sludge respiration inhibition. The 96h fish study with Triglyme was used for read across to Diglyme (see Section 6.1.1) for justification


 Fish: OECD 203  LC50 (96h)  > 5000 mg/L  Read across from Triglyme
 Daphnia: OECD 202 EC50 (48h) 943 mg/L Key Study
 Algae: OECD 201 ErC50 (72h) > 10000 mg/L Key Study
 Microorganisms (Sludge) OECD 209 NOEC (3h) 1067 mg/L Key Study
   EC50 (3h) > 5000 mg/L Key Study


The short-term ecotoxicity data were used for the derivation of the PNEC aqua intermittent release (see Section 6 Diglyme PNEC).




Algae:OECD 201  ErC10 (72h)8318 mg/L Key Study
 Daphnia: OECD 211 NOEC (21d) 320 mg/L Key Study


The algae ErC10 (72h) and the daphnia NOEC (21d) were used to derive the PNEC aqua for continuous release (see Section 6 Diglyme PNEC).