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Toxicity to soil macroorganisms except arthropods

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Description of key information

Eisenia fetida

14 d LC50>47.4 mg a.i./kg dry soil

14 d EC50>47.4 mg a.i./kg dry soil

14d-NOEC and LOEC, based on appearance and behavior: > 47.4 mg act. ingr./kg dry soil (nominal each)

OECD guideline 207, RL1, GLP; read-across from MDEA-Esterquat C16-18 and C18 unsatd.

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:
47.4 mg/kg soil dw

Additional information

No experimental data are available for the target substance MDIPA Esterquat C16-18 and C18 unsatd.  However, an acute toxicity study in earthworms is available for the source substance MDEA-Esterquat. A justification for read-across is given in the general endpoint summary Terrestrial toxicity.In a 14-day acute toxicity study, earthworms (Eisenia fetida) were exposed to MDEA-Esterquat C16-18 and C18 unsatd.  at 0, 2.20, 4.74, 10.2, 22.0, 47.4 mg a.i./kg dry soil (artifical soil). The experiment was carried out according to OECD TG 207. The 14 day LC50 value was determined to be >47.4 mg a.i./kg soil dry weight (nominal). The 14 d EC50 was >47.4 mg a.i./kg dry soil. The 14 d NOEC and LOEC, based on appearance and behaviour was >47.4 mg a.i./kg dry soil. No compound related toxicity effects were noted.

This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with earthworms.

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