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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards with acceptable restrictions.

Data source

Reference
Reference Type:
publication
Title:
Boric acid ointment: A study of possible intoxication in the treatment of burns.
Author:
Pfeiffer CC, Hallman LF & Gersh I.
Year:
1945
Bibliographic source:
J. Amer. Med. Assoc. 128 (4) 266 - 274.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
Study pre-dates GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Boric acid
EC Number:
233-139-2
EC Name:
Boric acid
Cas Number:
10043-35-3
Molecular formula:
H3BO3
IUPAC Name:
Boric acid
Details on test material:
- Name of test material: Boric acid
- Molecular formula: H3BO3
- Molecular weight: 61.8
- Smiles notation:B(OH)3
- Substance type: Inorganic
- Physical state: Solid
- Analytical purity: > 99.9 % w/w
- Stability under test conditions: Stable
- Other: White and odourless.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
40 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 330 mg/kg bw
Based on:
test mat.
Clinical signs:
The pre-lethal symptom in these animals was depression.

Applicant's summary and conclusion

Conclusions:
The LD50 in rats was 1330 mg/kg bw. The pre-lethal symptom in these animals was depression.