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EC number: 219-154-7 | CAS number: 2374-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Wareham Waste Water Treatment Plant, Wareham, Massachusetts
- Preparation of inoculum for exposure: passed through a 2-mm sieve, recombined, and centrifuged at 1000 rpm for 10 minutes. The supernatant was discarded, the sludge was washed with mineral salt medium and the contents were centrifuged at least once again and the supernatant was discarded. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Solubilising agent (type and concentration if used): Since the test substance is insoluble, a stock solution was not prepared. Instead, approximately 0.0883 g (equivalent to 0.0300 g carbon; 34.0% carbon) of 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane was weighed onto small glass dishes and then the test substance was completely rinsed into each respective test or toxicity control vessel.
- Test temperature: 22 ± 2 ºC
- Aeration of dilution water: Yes
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 4-L glass bottle with a rubber stopper into which one stainless steel needle with a Luer-Lok connection and two pieces of glass tubing were inserted.
- Number of culture flasks/concentration: Two
SAMPLING
On test days 1, 3, 6, 9, 14, 19 and 23, a 7-mL sample was removed from the first KOH carbon dioxide trap on each test system and analysed for CO2 evolution. On day 28, 1 mL of concentrated HCl was added to each test vessel after pH measurement to terminate biological activity. Aeration was continued overnight to drive any residual inorganic carbon from the test vessels. After overnight aeration, 7-mL samples for analysis of CO2 evolution were removed from the first and second traps.
The amount of evolved CO2 in each trap was determined using a Shimadzu TOC V-CPH Carbon Analyzer.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Toxicity control: Yes - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Toxicity control indicated no inhibition.
- Results with reference substance:
- The reference substance achieved 78.79% degradation by day 6 and approximately 85% degradation by day 14
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Biodegradation of 0% in 28 days (CO2 evolution) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Table 1:CO2evolved (mg/l) and calculated % biodegradation for inoculum blank, test substance, reference substance and toxicity control
Type of suspension |
1d |
3d |
6d |
9d |
14d |
19d |
23d |
28d |
||||||||
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
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Inoculum Blank (mean of two replicates) |
3.58 |
- |
6.81 |
- |
11.56 |
- |
14.28 |
- |
17.65 |
- |
20.24 |
|
21.04 |
|
25.04 |
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Test substance (mean of two replicates) |
3.65 |
0.19 |
6.74 |
-0.20 |
10.15 |
-3.83 |
12.33 |
-5.30 |
16.33 |
-3.59 |
19.44 |
-2.18 |
20.28 |
-2.08 |
23.82 |
-3.33 |
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Reference substance |
13.71 |
27.62 |
29.61 |
62.16 |
40.45 |
78.79 |
44.85 |
83.39 |
48.82 |
84.99 |
52.18 |
87.09 |
51.66 |
83.50 |
54.92 |
81.49 |
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Toxicity control |
3.89 |
0.43 |
26.02 |
26.19 |
36.06 |
33.41 |
39.95 |
35.01 |
43.12 |
34.73 |
45.66 |
34.66 |
45.75 |
33.69 |
46.73 |
29.58 |
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Description of key information
Biodegradation in water: screening tests: 0% in 28 days (CO2 evolution).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Biodegradation of 0% in 28 days (CO2 evolution) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.