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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP or O.E.C.D. Testing Guideline Study, no details on the study design or rationales for the selection of the doses.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2007

Materials and methods

Principles of method if other than guideline:
Standard acute dermal exposure practice.
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
As per Vinyl Neodeconoate IUCLID 4 Data Set

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
Animals were 12 - 13 weeks of age when placed on-study.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The 24 h LD50 in male and female Wistar rats was determined by method of Noaks and Sanderson (1969). Two groups of rats (two males and two females/group) age 12-13 weeks, were used in this test. Vinyl neodecanoate (2 and 4 ml/kg per group) was placed on the shaved dorso-lumbar skin and was kept in contact with skin by impermeable dressings of aluminum foil and water proof plaster. The dressing was removed after 24 hr and the exposed skin was washed with diluted detergent solution and then rats were watched for signs of toxicity during 9 days.
Duration of exposure:
24 hr
Doses:
2.0 and 4.0 ml/kg of body weight
No. of animals per sex per dose:
2
Control animals:
no
Details on study design:
Two groups of rats (two males and two females/group) age 12-13 weeks, were used in this test. Vinyl neodecanoate (2 and 4 ml/kg per group) was placed on the shaved dorso-lumbar skin and was kept in contact with skin by impermeable dressings of aluminum foil and water proof plaster. The dressing was removed after 24 hr and the exposed skin was washed with diluted detergent solution and then rats were watched for signs of toxicity during 9 days.
Statistics:
No data

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 4 mL/kg bw
Mortality:
None
Clinical signs:
None
Body weight:
No data
Gross pathology:
No data
Other findings:
None

Any other information on results incl. tables

The application of vinyl neodecanoate under occlusive conditions at doses of 2 and 4 ml/kg to skin of rats for 24 hr did not produce any mortality or signs of toxicity. Thus the acute percutaneous (LD50) was estimated to be greater than 4 ml/kg, or > 3540 mg/kg bw when correcting for density (0.885 g/ml).

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information
Conclusions:
Vinyl Neodeconate was not acutely toxic to rats following 24 hours of occlusive dermal exposure to a dose of > 3.5 grams/Kg of body weight.
Executive summary:

Two groups of rats (two males and two females/group) were dermally exposed to Vinyl neodecanoate (2 and 4 ml/kg per group) under occlusion for 24 hr. The obsrvation period was 9 days. The application of vinyl neodecanoate at doses of 2 and 4 ml/kg to skin of rat for 24 hr did not produce any mortality or clinical signs toxicity. Thus the acute dermal LD50 was estimated to be greater than 3540 mg/kg of body weight.