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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a GLP study, not many details on the study design and the documentation of the study not sufficient in assessment.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2007

Materials and methods

Principles of method if other than guideline:
Other
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
As per Vinyl Neodeconoate IUCLID 4 Data Set

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
Adult male and female Wistar rats aged 12 weeks were used in this experiment

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
Rats were dosed with undiluted vinyl neodecanoate by intraesophageal intubation.
Doses:
1.25, 2.5, 5.0, 10 ml/kg
No. of animals per sex per dose:
2
Details on study design:
Adult male and female Wistar rats aged 12 weeks were used in this experiment. Rats were dosed with undiluted vinyl neodecanoate at (1.25, 2.5, 5.0, 10 ml/kg) by intraesophageal intubation. Food and water were freely available throughout a 9 day observation period.
Statistics:
No data

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 10 mL/kg bw
Mortality:
None
Clinical signs:
None
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

Based on the experimental results, the acute oral LD50 was estimated to be greater than 10 ml/kg or correcting for density of the test substance, > 8850 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information
Conclusions:
Vinyl neodecanoate is of low acute toxicity to laboratory rats by the oral routes of exposure.
Executive summary:

Laboratory rats (2/sex/group) were treated with Vinyl Neodecanoate by oral gavage to determine the acute oral LD50 value. No mortality or clinical signs were observed. The estimated oral LD50 value for laboratory rats was > 8850 mg/kg of body weight.