Registration Dossier
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EC number: 256-905-8 | CAS number: 51000-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 1. Study was an in vitro protocol which would detect and measure only some mechanisms of elimination. 2. Study was not conducted according to a valid and/or internationally accepted testing guideline.
Data source
Reference
- Reference Type:
- other: Unpublished report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
Test material
- Reference substance name:
- Vinyl neodecanoate
- EC Number:
- 256-905-8
- EC Name:
- Vinyl neodecanoate
- Cas Number:
- 51000-52-3
- Molecular formula:
- C12H22O2
- IUPAC Name:
- ethenyl 2,2-dimethyloctanoate
- Details on test material:
- Vinyl Neodecanoate IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- other: In vitro
- Vehicle:
- acetone
- Details on exposure:
- In vitro
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10
- Details on study design:
- This in vitro study was designed for the testing Vinyl Neodeconoate's disappearance from a buffered solution incorporating whole liver crude homogenate preparations, using Michaelis-Menten kinetics. Liver homogenate was prepared from livers of adult male Fischer 344 rats in sodium phosphate buffer (pH 7.4). Approximately 2 g of liver were minced and rinsed with buffer. Liver was homogenized using a Polytron Homogenizer (~ 15 sec) at a speed setting of 4. The homogenate was then diluted with 50 mM sodium phosphate buffer (pH 7.4) so as to provide concentrations of 3, 1, 0.3 and 0.1% (v/v) homogenate. The homogenates were spiked with test substance prepared in acetone (5 mM). Two hundred-five microliters (205 µl) of liver homogenate were used in all experiments. Standards solutions were prepared by using buffer instead of liver homogenate. Each experiment wasconducted in duplicate. Five microliters of spiking solution were introduced into the homogenate and blank tubes. Tubes were incubated at 37°C for a period of time (not specified in the study). The reaction was terminated by addition of 785 µl of acetonitrile. Tubes were centrifuged, supernatant was collected and analyzed by GC equipped with column (DB-1, Megabore, 30 m x 0.53 mm ID, 5 micrometer film thickness) and flame ionization detector and Hewlett Packard 3396 A Integrator.
- Statistics:
- Linear regression of Lineweaver-Burk plots served to establish Michaelis-Menten rate constants (Km) and maximum velocities (Vmax).
Results and discussion
- Preliminary studies:
- A preliminary test with vinyl adipate was conducted to determine the appropriate concentration of liver homogenate to be used in the definitive testing with Vinyl Neodeconate.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
There was no attempt to fractionate the liver homogenate, and no attempt to determine actual metabolites. There was no attempt to measure GSH depletion either. In general, no disappearance of vinyl neodecanoate was detected in 2 separate tests at any of the concentrations.
Applicant's summary and conclusion
- Conclusions:
- No dissipation kinetic constants were established for Vinyl Neodeconoate and no metabolites were identified.
- Executive summary:
In vitro preparations of rat liver homogenate were used to assess the disappearance of Vinyl Neodecanoate as a function of time at five different concentrations. No disappearanve of Vinyl Neodecanoate was observed in two idependent studies over the concentration range employeed. Therefore, no in vitro dissipation kinetics were established for Vinyl Neodecanoate.
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