Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Vinyl Neodeconoate induced no evidence of neurtoxicity in an O.E.C.D. 422 Testing Guideline oral rat screening study conducted up to a high dose level of 1000 mg/kg/day.  

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Dose descriptor:
1 000 mg/kg bw/day

Additional information

Vinyl Neodeconoate did not induce signs of neurtoxicity in an O.E.C.D. 422 Testing Guideline oral gavage rat screening study based on the results of a Functional Observational Battery and motor activity assessment. The NOAEL for this endpoint was 1000 mg/kg/day. The Worker Inhalation DNEL based on ECHA RIP 3.2 Chapter R.10 guidance for this endpoint is estimated to be > 1.45 ppm TWA.

Therefore, the Worker long-term Inhalation DNEL derived from the 90 -day rat subchronic inhalation study of 0.6 ppm is considerd to be protective.

Justification for classification or non-classification

Based on the available study data Vinyl Neodeconoate does not meet the criteria for Classification and Labeling as R48 due to neurological findings as established by EU Directive 67/548/EEC Annex 6 and the CLP.