Tetrabutyltin

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 June 2004 to 21 August 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

<= 0 g/L

Temp.:

20 °C

pH:

5.4 - 5.5

Details on results:

Recovery of analysis of the sample procedure was assessed and proved adequate for the test. At a nominal concentration of 0.2 mg/L, a mean percentage recovery of 88.6 % was obtained.
Concentrations have not been corrected for recovery of analysis.

Table 1: Summary of Results

Sample	Time shaken at 30 degrees C	Time equilibrated at 20 degrees C	Concentration (g/L)	Solution pH
1	24	24	<9.64 x 10 ^-5	5.4
2	48	24	<9.64 x 10^-5	5.5
3	72	24	<9.64 x 10^-5	5.5

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 10 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.

Conclusions:

Interpretation of results: insoluble (< 0.1 mg/L)
The water solubility of tetrabutyltin was determined to be less than or equal to 9.64 x 10^-5 g/L of solution at 20 degrees C.

Executive summary:

The water solubility of tetrabutyltin was determined to be less than or equal to 9.64 x 10^-5 g/L of solution at 20 degrees C, using the flask method, Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

The key study, (O'Connor BJ & Mullee DM, 2004) was chosen as the study is conducted to a recognised guideline, has a reliability rating 2 according to the criteria of Klimisch et al. (1997) and is the most recent study.

The water solubility for this study was determined to be less than or equal to 9.64 x 10^-5 g/L of solution at 20 degrees C, using the flask method, Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Key value for chemical safety assessment

Water solubility:

0 g/L

at the temperature of:

20 °C

Additional information

The water solubility for the key study was determined to be less than or equal to 9.64 x 10^-5 g/L of solution at 20 degrees C, using the flask method, Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The test substance is classed as insoluble.

The following supporting studies are also available for this endpoint:

- The water solubility was estimated to be 6.4E-005 mg/L at 25 deg C according to the SRC.

- Schering AG conducted a test following OECD Guideline No. 105, the column elution method was used for the determination of the water solubility of tetra-n-butyltin. A value of 8.8 mg/L was ascertained. However, the analytical method was not compound specific and hence will include contributions from more water soluble tin impurities etc. Therefore, the actual solubility is likely to be less than the reported value. Therefore a reliablity rating of 3 has been assigned according to the criteria of Klimisch et al. (1997).

- The water solubility was estimated to be 1.889 mg/L at 25 deg C according to EPIWIN estimations.