Registration Dossier
Registration Dossier
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EC number: 203-453-4 | CAS number: 107-02-8
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Inhalation
chicken (Gallus sp.): 27 d LOEC=113–454 mg acrolein/m³
Oral exposure
mallard duck (Anas platyrhynchos): LD50=9.1 mg/kg body weight
Key value for chemical safety assessment
Additional information
1. European Union Risk Assessment Report of Acrolein (EU, 2001)
A 7-days dietary study is performed with the adult starling Sturnus vulgaris. The LD50was found to be >100 mg/kg bw. However, it has to be noted that little information is available on test conditions and test substance. Only two birds per dose were tested.
2. Agreement with further international Reports and Studies published after finalisation of the EU Risk Assessment Report 2001
None
3. Substantial disagreements in comparison to further international Reports to European Union Risk Assessment Report 2001
None
4. Additional aspects in further international Reports
Inhalation
WHO (2002); Canadian EPA (1999): In chickens (Gallus sp.), there was tracheal damage at concentrations of 113–454 mg acrolein/m3 for up to 27 days. As only a short abstract is available the results of this test will only be used as supportive information.
Oral exposure
WHO (2002); Canadian EPA (1999): With oral exposure to acrolein, the LD50for mallards (Anas platyrhynchos) is 9.1 mg/kg body weight, and treatment levels as low as 3.3 mg/kg body weight produce signs of intoxication, such as regurgitation, ataxia, imbalance, and withdrawal.
5. Additional information in newer Studies, not included in the European Union Risk Assessment Report 2001 or further cited international reports
None
6. Conclusions
Inhalation
In chickens (Gallus sp.), there was tracheal damage at concentrations of 113–454 mg acrolein/m3 for up to 27 days. As only a short abstract is available the results of this test will only be used as supportive information.
Oral exposure
With oral exposure to acrolein, the LD50for mallards (Anas platyrhynchos) is 9.1 mg/kg body weight, and treatment levels as low as 3.3 mg/kg body weight produce signs of intoxication, such as regurgitation, ataxia, imbalance, and withdrawal.
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