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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Waiving of short-term (28 days) repeated dose toxicity study due to available chronic toxicity studies according to the REACH legal text Annex VIII: "Standard information requirements for substances manufactured or imported in quantities of 10 tonnes or more", Column 2.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

1,3-propanesultone has been tested in several chronic toxicity studies and has been found to be carcinogenic in rats and mice by any of several routes of administration (i.e. oral, dermal, subcutaneous, i.v., transplacental) - see chapter Carcinogenicity. Based on the available data regarding carcinogenicity 1,3-propanesultone is subject to classification and labelling: Carc. 1B, H350 according to Regulation 1272/2008/EC. According to the REACH legal text Annex VIII: "Standard information requirements for substances manufactured or imported in quantities of 10 tonnes or more", Column 2, a short-term toxicity study (28 days) does not need to be conducted if a reliable sub-chronic or chronic toxicity study is available, provided that an appropriate species and route of administration were used, as is the case for 1,3-propanesultone. Therefore, a repeated dose study does not need to be performed.

Justification for classification or non-classification

No data available regarding repeated dose toxicity.