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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
INITIAL SUBMISSION: TOXICITY STUDIES OF 1,2-OXATHIOLANE,2,2-DIOXIDE WITH COVER LETTER DATED 09/01/92
Author:
OTS
Year:
1992
Bibliographic source:
Microfiche No. OTS0555330 , Doc ID 88-920009014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
One drop of the undiluted substance was instillated in the eye of one rabbit.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
1 drop
Duration of treatment / exposure:
- single application
Observation period (in vivo):
The animals were observed at 1 h, 24 h, 48 h and up to 14 days afterwards.
Number of animals or in vitro replicates:
no data
Details on study design:
One drop of the undiluted substance was instillated in the eye of one rabbit.

Results and discussion

In vivo

Resultsopen allclose all
Remarks on result:
other: No scores given in the publication.
Remarks:
Slight to severe erythema and edema of conjunctiva, lids and nicitating membrane as well as opaque cornea, staining and discharge were observed initially, at the 1, 24 and/or 48 hours reading. At the end of the 14-day observation period slight erythema and opaque cornea was still present.
Irritation parameter:
cornea opacity score
Time point:
24/48/72 h
Remarks on result:
other: No scores given in the publication.
Irritation parameter:
iris score
Time point:
24/48/72 h
Remarks on result:
other: No scores given in the publication.
Irritation parameter:
conjunctivae score
Time point:
24/48/72 h
Remarks on result:
other: No scores given in the publication.
Irritation parameter:
chemosis score
Time point:
24/48/72 h
Remarks on result:
other: No scores given in the publication.

Any other information on results incl. tables

The following symptoms were recorded and presented in the study report on respective time points after instillation of 1 drop in the rabbits eye:

"Initial: Erythema with slight blinking , rubbing with paw or eye held closed.

1 hour: Slight to moderate erythema of conjunctiva, lids and nicitating membrane - as well as moderate to severe edema of the same.

24 hours: Gross edema and erythema throughout, cornea opaque, purulent descharge, staining throughout.

48 hours: Erythema reduced to moderate, edema as before, purulent discharge.

14 days: Edema reduced completely, erythema only slight, cornea opaque."

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
CLP: Eye Damage 1, H318