Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
INITIAL SUBMISSION: TOXICITY STUDIES OF 1,2-OXATHIOLANE,2,2-DIOXIDE WITH COVER LETTER DATED 09/01/92
Author:
OTS
Year:
1992
Bibliographic source:
Microfiche No. OTS0555330 , Doc ID 88-920009014

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: undiluted and 10% in water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10%
Doses:
50 - 3200 mg/kg bw
No. of animals per sex per dose:
- No of animals: 16 rats
- Sex: not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 100 - < 200 mg/kg bw
Based on:
test mat.
Mortality:
Mortality occured after 2 hours - 1 day.
Clinical signs:
Animals were moderately to very weak.
They showed prostration, salivation, dark eyes, tremor, gasping, diarrhea and convulsions.
Gross pathology:
No abnormalities were found.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
CLP: Acute Oral 3, H301