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Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: Exposure related observations in humans
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
review article or handbook
Title:
1,3-Propane sultone, an extremely potent experimental carcinogen: what should be expected in humans?
Author:
Bolt, M. H. and Golka, K.
Year:
2004
Bibliographic source:
Toxicology Letters 151, 251–254

Materials and methods

Type of study / information:
Case studies and related malignancies observed in persons exposed to 1,3-propane sultone are described.
Endpoint addressed:
carcinogenicity

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

During manufacturing mainly in the 1950s and 1960s exposure of a limited amount of workers could have occurred and the medical history of some cases could be traced. As cerebral gliomas are the main systemic tumours induced by 1,3-propanesultone experimentally, the occurrence of a glioblastoma among previously exposed persons appears conspicuous. Three intestinal malignancies were recorded among the cases observed. Also noteworthy is one case of a duodenal carcinoma, normally a rare human malignancy. Two haematopoietic/lymphatic malignancies of different nature have been observed, and there was one case of a renal cell carcinoma. These observations within a group of persons exposed to 1,3-propanesultone appear consistent with the expectations from the available animal studies.

Applicant's summary and conclusion